A PI intending to work with a biohazardous material must complete the following steps to have a research protocol approved by the IBC.

• Complete and submit a Biosafety Protocol Registration Form, including a biohazardous material specific attachment, to the IBC at  biosafe@isu.edu.
• Coordinate a laboratory inspection with the ISU Biosafety Officer to ensure the proposed lab area is appropriate for work with biohazardous materials.
• Complete a lab specific Biosafety Manual utilizing the biosafety manual template and submit it to the IBC.

The IBC will review the form submissions, comments from the lab inspection, and the completed biosafety manual to determine if additional information or modifications are required.  

The PI will receive written notification from the IBC when all requirements are met and the protocol is approved by the IBC. 

Researchers working on a project requiring IBC approval are required to take biosafety training via ISU's online training system, CITI Training. 

CITI Training Log-in

All researchers working on a project requiring IBC approval must take one of the two following courses. 

Group 1- Handling Biohazards (researchers handling handling biohazardous material)   

Group 9 - Biosafety Overview (researchers NOT handling biohazardous materials)

Additional courses are required as determined by the type of biohazard and the researcher's applicable work activity.  Once in the CITI training system, go to Question 8 to find the other potentially applicable training courses.

Group 2 - Institutional Biosafety Committee Member Training

Group 3 - OSHA Bloodborne Pathogens

Group 4 - Shipping and Transport of Regulated Biological Materials

Group 6 - Dual Use Research of Concern (DURC)

Group 8 - USDA Permits Soil/Animal/Plant

Completed registration forms must be submitted to biosafe@isu.edu before the submission deadline listed on the meeting schedule to be considered at the next IBC meeting.  Consideration deadlines are the first Tuesday of the month for the meeting on the third Tuesday of the month.  

Protocol Registration Forms

Biosafety Registration Form (required for all protocols)

Biohazard Specific Attachment Form (include the appropriate attachment with the registration form above).

Attachment A - Pathogen

                    Attachment B - rDNA/Synthetic DNA

Attachment C - Toxin

Attachment D - Tissue/Body Fluid

Attachment E - Cells/Cell Lines

Attachment F - CRISPR Cas9

Modification to Approved Protocols

Laboratory Safety Manual Templates

BSL1 Laboratory Biosafety Manual

BSL2 Laboratory Biosafety Manual

Policies

• ISU Laboratory Safety ISUPP 7110
• Principal Investigator and Co-Investigator Eligibility and Responsibility ISUPP 7090
• Misconduct in Research and Scholarship ISUPP 7060

Select Agents Regulations

• Select Agents and Toxins List
• 7 CFR Part 331 - Agriculture
• 9 CFR Part 121 - Animals and Animal Products
• 42 CFR Part 73 - Public Health (CDC)

Guidelines 

• NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules
• CDC Biosafety in Microbiological and Biomedical Laboratories (BMBL)

Biosafety Publications

• Guidelines for Biosafety Laboratory Competency

ISU Biosafety Handbooks

• Institutional Biosafety Committee Handbook
• Principal Investigator IBC Protocol Handbook