James Groome

James Groome, Ph.D.

Professor
Molecular Neurobiology

Office: Life Sciences 136B

(208) 282-5416

groojame@isu.edu

Groome Laboratory of Molecular Neuroscience

We study molecular neuroscience, ion channel disorders, and pathology.

Education

1988, Ph.D. Zoology, University of New Hampshire, Durham, NH
1981, B.A. Biology, Wake Forest University, Winston-Salem, NC

1989-1995 Postdoctoral fellow, Neuroethology, Utah State University, Logan, UT

Biographical Sketch

My laboratory studies ion channel proteins of nerve and muscle. We investigate the basis for inherited diseases of these genes, as channelopathy disorders such as myotonia and periodic paralysis. We also use electrophysiological and computational approaches to study the mechanisms of voltage-gating in ion channels. A new area of research is the study of neurotransmitter receptors with a focus on the role of neuronal, nicotinic acetylcholine receptors as a target of drug therapy in the treatment of Parkinson's disease.

Teaching

BIOL 4463/5563 Human Pathophysiology and Lab
BIOL 4481/4482 Independent Problems
BIOL 4491/4492 Senior Seminar
BIOL 4499/5599 Foundations in Neuroscience
PTOT 4402/5502 Clinical Neuroscience
BIOL 4460/5560 Neuroscience
BIOL 4415L/5515L Human Neurobiology Laboratory
BIOL 6691/6692 Graduate Seminar
BIOL 6648 Thesis
BIOL 6650 Graduate Problems

Selected Publications

Groome JR, Lehmann-Horn F, Fan C, Wolf M, Winston V, Merlini L, Jurkat-Rott K. 2014. Nav1.4 mutations cause hypokalemic periodic paralysis by disrupting IIIS4 movement during recovery. Brain Advance Access published Feb 18, 2014. doi:10.1093/brain/awu015

Sambasivarao SV, Roberts J, Bharadwaj BS, Slingsby JG, Rhole-der C, Mallory C, Groome JR, McDougal OM, Maupin CM. 2014. Acetylcholine promotes binding of a-conotoxin MII for a3b2 nicotinic acetylcholine receptors. Chem Biochem 15 (3), 413-424. doi:10.1002/cbic.201300577.

Groome JR, and Winston V. 2013. S1-S3 counter charges in the voltage sensor module of a mammalian sodium channel regulate fast inactivation. Journal of General Physiology 141, 601-618. doi/10.1085/jgp.201210935.

Dong K, Du Y, and Groome JR. 2010. A negative charge in transmembrane segment 1 of domain II of the cockroach sodium channel is critical for channel gating and action of pyrethroid insecticides. Toxicology and Applied Pharmacology 247, 53-59

Groome JR, Larsen M, and Coonts A. 2008. Differential effects of paramyotonia congenita mutations F1473S and F1705I on sodium channel gating. Channels 2, 1-12.

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