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Acetylcholine…a
common neurotransmitter, particularly involved in long term
memory formation. Specifically released at neuromuscular
junctions, it’s present at higher levels during sleep.
ACTH…
also called corticotropin, this stress-related hormone is
produced by the pituitary gland. It’s released into your
system when you experience injury, emotion, pain, infections or
other trauma.
Adrenaline…(also
known as epinephrine) under stress, fear or excitement, this
hormone is released from your adrenal gland into your
bloodstream. When it reaches your liver, it stimulates the
release of glucose for rapid energy. Abrupt increases caused by
anger can constrict heart vessels, requiring the heart to pump
with higher pressure. Also known as epinephrine.
Amygdala…
an almond-shaped mass of gray matter located in the middle of
the brain (anterior temporal lobe), that is thought to be the
critical processor area for senses. It’s connected to the
hippocampus, and plays a role in emotionally-laden memories.
Contains a huge number of opiate receptor sites implicated in
rage, fear and sexual feelings, and .is concerned with the
expression and regulation of emotion and motivation.
Axon…the
long fiber extending from the brain cell (neuron) that carries
the output (an electrical nerve impulse) to other neurons. Can
be up to a meter long. Axons build up a white fatty
(lipoprotein) insulation called myelin.
Brain stem…
located at the top of the spinal cord. Links the lower brain
with the middle of the brain and cerebral hemispheres. Often
referred to as the lower brain or reptilian brain in Paul
McLean’s triune brain model.
Broca’s area…
part of the left frontal lobe in the cerebrum. It converts
thoughts into sounds (or written words) and sends the message to
the motor area. Impulses go first to Wernicke’s area, in the
right hemisphere, then to Broca’s area.
Cell migration...
The movement of a cortical neuron during development to its
proper position on the cortical wall.
Cerebellum…
a cauliflower-shaped structure located below the occipital area
and next to the brain stem. The word is Latin for “Little
Brain.” Traditionally, research linked it to balance, posture,
coordination and muscle movements. It relays signals to the
muscles from higher brain regions where decisions are made.
Newer research has linked it to cognition, novelty and emotions.
Cerebral cortex…this
is the newspaper-sized, ¼” thick, outermost layer of the
cerebrum. It is wrinkled, six layers deep and packed with brain
cells (neurons). It controls higher mental functions, such as
thinking, planning, remembering, and analyzing. Cortex is Latin
for “bark” or “rind.”
Cerebrum…this
is the largest part of the brain, composed of the left and right
hemisphere, joined by the corpus callosum. It has frontal,
parietal, temporal (right and left) and occipital lobes.
Cingulate gyrus…this
structure lies directly above the corpus callosum. It mediates
communication between the cortex and the middle of the brain
structures.
Corpus callosum…a
white-matter bundle of about 200 million nerve fibers which
connect the right and left hemispheres. Located in the middle of
the brain.
Cortex...
Latin for Bark. See CEREBRAL CORTEX.
Cortical ladders... a
phrase often used to describe long glial cells in the
cortex. For normal development to occur, neurons must
climb these cortical ladders at the right time, and must reach
the right destinations.
Cortical neuron...
a brain cell that is located in the cerebral cortex.
Critical period...
a time span when a particular part of the brain is most apt to
change and most vulnerable to environmental influences.
Dendrites…these
are the strand-like, or hair-like, fibers emanating from the
cell body. Similar to spider webs or cracks in a wall, they are
the receptor sites for axons when they connect to make a
synapse. Each neuron usually has many, many dendrites.
Dendritic tree...
a network that forms as the number of dendrites in a neuron
multiplies. The growth of dendritic trees explains, in
part, why individual neurons get bigger and heavier as the brain
develops.
Dopamine…a
powerful and common neurotransmitter primarily involved in
producing a positive mood or feelings. Secreted by neurons in
the substantia nigra, mid brain and hypothalamus, it plays a
role in movements, too. It’s commonly in shortage in patients
suffering from Parkinson’s Disease.
Endorphin…a
natural opiate, this neurotransmitter is similar to morphine. It
is produced in the pituitary gland. Protects against excessive
pain and is released with ACTH and enkephalins into the brain.
Enkephalin…this
morphine-like substance consists of five opiate-type amino
acids. Released into the brain with ACTH and endorphins to
combat pain.
Event Related Potential (ERD)…brain
responses to some "event". An event may be sensory
(sound, feel, taste, or visual) or mental (memory
recognition). Electrical signals are measured on the scalp
using the electroencephalogram (EEG).
Frontal lobes…one
of four main areas of the cerebrum, the upper brain area.
Controls voluntary movement, verbal expression, problem-solving,
will power and planning. The other three areas of the cerebrum
are the occipital, parietal and temporal (right and left).
GABA…gamma-aminobutyric
acid, this neurotransmitter acts as an inhibitory agent, an
“off” switch.
Glial…a
non-neuronal cell, these are one of two types of brain cells
(the other is a neuron). These outnumber neurons 10-1, and are
also known as interneurons. In the cerebral cortex, long glial
cells form “critical ladders” that neurons must climb to
reach their proper positions during brain development.
This process is known as neuronal migration or cortical cell
migration. They also carry nutrients, speed repair and may form
their own communication network. They produce myelin and assist
neurons in their migration to the cortex. Short for neuroglia.
Hemisphere, right and
left... the two
halves of the cerebrum.
Hippocampus…found
deep in the temporal lobe, central to the middle of the brain
area. It is crescent-shaped and has been shown to play an
important role in organizing memories, as well as handling some
visual and spatial information.
Hypothalamus…located
in the bottom center of the mid-brain area. A complex
thermostat-like structure that influences and regulates
appetite, body temperature, hormone secretion, digestion,
sexuality, circulation, emotions and sleep.
Lateralization…refers
to the activity of using one hemisphere more than another. The
term “relative lateralization” is more accurate since we are
usually using at least some of the left and right hemisphere at
the same time.
Limbic system…an
older term coined by Dr. Paul McLean in the 1950’s. This is a
group of connected structures in the mid brain area which
include the hypothalamus, amygdala, thalamus, fornix,
hippocampus and cingulate gyrus.
Lower brain…this
is the lower portion of the brain composed of the upper spinal
cord, medulla, pons and some believe the reticular formation. It
sorts sensory information and regulates our survival functions
like breathing and heart rate.
Medulla…located
in the brain stem, it channels information between the cerebral
hemispheres and the spinal cord. It controls respiration,
circulation, wakefulness, breathing and heart rate.
Myelin…a
fatty white (lipoprotein) shield that coats and insulates axons.
Habits may be a result of myelinated axons.
Neural pathway...
a series of synapses that forms a network in the brain.
These pathways can be activated by a particular experience.
Norepinephrine…(also
known as noradrenaline) a common neurotransmitter, primarily
involved in our arousal states: fight or flight, metabolic rate,
blood pressure, emotions and mood.
Neurons…one
of two types of brain cells. We have about 100 billion of these.
Receives stimulation from its branches known as dendrites.
Communicates to other neurons by firing a nerve impulse along an
axon.
Neuronal migration...
see CELL MIGRATION.
Neuroplasticity...
the capacity of the brain to change or adapt in response either
to experience or to damage.
Neurotransmitters…our
brain’s biochemical messengers. It is believed that we have 50
- 100 types of them. These usually act as the stimulus that
excites a neighboring neuron or an inhibitor to suppress
activation.
Occipital lobe…located
in the rear of the cerebrum. One of the five lobes of the upper
brain with vision processing as a function. The other lobes are
the frontal, parietal, and the two temporal.
Oxytocin…a
peptide also known as the “commitment molecule.” It’s
released during sex and pregnancy and influences
“unlearning” and pair bonding.
Parietal lobe…the
top of our cerebrum. One of five lobes of the upper brain. This
area deals with reception of sensory information from the
contralateral body side. It plays a part in reading, writing
language and calculation. The other lobes are the frontal,
occipital, and the two temporal.
Pons…located
near the top of the brain stem, above the medulla. It’s a
critical relay station for our sensory information.
Potentiation…the
strengthening of a synapse for the making of learning. This
strengthening can persist for a long time. This is known as
long-term potentiation.
Pruning...
a term often used to describe an important feature of brain
development-the selective elimination of synapses. This usually
occurs at around 24 months of age (the "terrible
twos").
Reticular formation…a
small structure, located at the top of the brain stem and bottom
of middle of the brain area. It’s the regulator responsible
for attention, arousal, sleep-awake, consciousness.
Serotonin…a
common neurotransmitter, most responsible for inducing
relaxation, regulating mood and sleep. Antidepressants (like
Prozac) usually suppress the absorption of serotonin, making it
more active.
Sheath...
the myelin layer covering the axon referred to as the myelin
sheath.
Synapse…the
means by which neurons communicate. When an axon of one neuron
releases neurotransmitters to stimulate the dendrites of another
cell, the resulting junction point (actually a gap) where the
reaction occurs is a synapse. The adult human has trillions of
synapses.
Temporal lobes…located
on the side of the cerebrum (in the middle of our upper brain,
near our ears), it’s an area believed responsible for hearing,
senses, language, learning and memory storage. The other major
cerebrum areas are the frontal, parietal and occipital lobes.
Thalamus…located
deep within the middle of the brain, it is a key sensory
"relay station" receiving input from the body's
sensory, motor, and other systems, dispatching them to the
appropriate region of the cerebral cortex. Its functions are
involved in hearing, muscle movement, retrieving memories.
Vasopressin…a
stress-related hormone that is responsible partly for our
aggression.
Vesicle... a small sac,
usually containing fluid. In a neuron, vesicles are
containers for neurotransmitters.
Wernicke’s area…the
upper back edge of the parietal and left temporal lobes. Here
the brain converts thoughts into language.
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