Biological Sciences

Gene M. Scalarone, Ph.D.

Gene M. Scalarone

Professor of Microbiology

Education

Biographical Sketch

Dr. Scalarone has been a faculty member at ISU since 1980. His interest in medical mycology research began in 1962 as a microbiology graduate student at the University of Oklahoma. After completion of the MS degree in Microbiology, Dr. Scalarone served in the U.S. Army Medical Service Corps as Chief of Microbiology at Letterman General Hospital in San Francisco for two years. After obtaining his PhD degree in Immunology in 1970 from the University of California-Berkeley he continued there as a Research Bacteriologist (Naval BIOLciences Laboratory, School of Public Health, UC Berkeley) working on various aspects of fungal immunology. The research included work on the development and evaluation of antigenic reagents for the immunodiagnosis of coccidioidomycosis and histoplasmosis as well as research on fungal vaccines and antifungal agents. In addition to the research D. Scalarone became involved with teaching various microbiology courses at the UC Berkeley Extension Division, San Jose State University and Sonoma State University. Here at ISU he has continued research on the development of improved immunoassays for the clinical diagnosis of blastomycosis and other systemic fungal diseases. Research funding has been obtained from a variety of sources including two major NIH grants which allowed for the development and testing of novel yeast phase lysate antigenic reagents. His work in medical mycology also led to a sabbatical at the Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan. Many undergraduates and over 35 graduate students (MS and PhD recipients) have participated in research in Dr. Scalarone's laboratory since 1980. His research has resulted in over 175 presentations at regional, national and international scientific meetings as well as over 50 publications in various microbiology and medical mycology journals. Research continues on the development and evaluation of methods for the immunodiagnosis of blastomycosis and other fungal diseases of humans and animals.

Teaching

Representative Publications

Searle, Amanda J, Vern Winston & Gene M. Scalarone. 2012. Blastomyces dermatitidis: Chitinase homology model, in-silico docking and inhibition assay. In Press. Open Journal of Medical Microbiology.

Christenson, Will, Rachel Horton, Kayla Campbell, Kelly Meacham, Amber Schroeder & G.M. Scalarone. 2011. Comparison of antibody detection with Blastomyces dermatitidis yeast lysate antigens in serum specimens from immunized rabbits and infected dogs. Open Journal of Immunology. 1:74-79.

Manandhar, Mandira & Gene M. Scalarone. 2009. Comparative studies on alpha 1-3 glucan in Blastomyces dermatitidis yeast lysate antigens and the use of the lysates for the detection of antibodies. Proceedings of the Pacific Division of the American Association for the Advancement of Science. 28:1.

Hatch, Wayne & Gene M. Scalarone. 2009. Comparison of colorimetric and chemiluminescent ELISAs for the detection of antibodies to Blastomyces dermatitidis. J. Med. Biol. Sciences. 3:1.

Scalarone, Anne R., Scalarone, Geoffrey M. & Scalarone, Gene M. 2007. Detection of antibodies in dogs with blastomycosis: Comparative studies using yeast lysate antigens prepared from isolates of Blastomyces dermatitidis from a Minnesota outbreak. Proceedings of the 49th Annual Meeting of the Idaho Academy of Science Vol 42, No. 2(CD).

Shurley, Jack F. and Gene M. Scalarone. 2007. Isoelectric focusing and ELISA evaluation of a Blastomyces dermatitidis human isolate. Mycopathologia. 164:73-76.

Shurley, Jack F. & Gene M. Scalarone. 2007. Comparison of Blastomyces dermatitidis yeast phase lysate antigens for their use as diagnostic reagents in the competitive inhibition ELISA for the detection of blastomycosis. J. Medical and Biological Sciences. 1(2):1-4.

Sestero. C.M. and G.M. Scalarone. 2006. Detection of IgG and IgM in sera from canines with blastomycosis using eight Blastomyces dermatitidis yeast phase lysate antigens. Mycopathologia. 162:33-37.

Sestero, C.M. and G.M. Scalarone. 2006. Detection of the surface BAD1 and alpha (1,3)-glucan in six different strains of Blastomyces dermatitidis using monoclonal antibodies. J. Medical and Biological Sciences. 1:1-7.

Shurley, J.F., A.M. Legendre and G.M. Scalarone. 2005. Blastomyces dermatitidis antigen detection in urine specimens from dogs with blastomycosis using a competitive binding inhibition ELISA. Mycopathologia. 160(2):137-142.

Bono, J.L., B. Jaber, M.A. Fisher, R.O. Abuodeh, E. O'Leary-Jepson, G.M. Scalarone and L.H. Smith. 2001. Genetic diversity and transcriptional analysis of the bys1 gene from Blastomyces dermatitidis. Mycopathologia. 152:113-123.

Axtell, R.C. and G.M. Scalarone. 2002. Serological differences in two Blastomyces dermatitidis isolates from different geographical regions of North America. Mycopathologia 153:141-144.

Axtell, R.C. and G.M. Scalarone. 2002. Serological differences in three Blastomyces dermatitidis isolates. Mycoses 45:1-6.

Abuodeh, Raed O., John Galgiani and Gene M. Scalarone. 2002. Molecular approaches to the study of Coccidioides immitis. Int. J. Med. Microbiol. 292:373-380.

Fisher, M.A., A.M Legendre and G.M. Scalarone. 1997. Immunologic and chemical characterization of glycoproteins in IEF fractions of Blastomyces dermatitidis yeast lysate antigen. Mycoses 40:83-90.

Fisher, M.A., J.L. Bono, R.O. Abuodeh, A.M. Legendre and G.M. Scalarone. 1995. Sensitivity and specificity of an isoelectric focusing fraction of Blastomyces dermatitidis yeast lysate antigen for the detection of canine blastomycosis. Mycoses 38:177-182.

Abuodeh, R.O. and G.M. Scalarone. 1995. Induction and detection of delayed dermal hypersensitivity in guinea pigs immunized with Blastomyces dermatitidis lysate and filtrate antigens. Journal of Medical and Veterinary Mycology 33: 19-25.

Bono, J.L., A.M. Legendre and G.M. Scalarone. 1995. Detection of antibodies and delayed hypersensitivity with Rotofor® preparative IEF fractions of Blastomyces dermatitidis yeast phase lysate antigen. Journal of Medical and Veterinary Mycology 33: 209-214.

Mikami, Y., G.M. Scalarone, N. Kurita, K. Yazawa, J. Uno and M. Miyaji. 1992. Synergistic postantifungal effect of flucytosine and fluconazole on Candida albicans. Journal of Medical and Veterinary Mycology 30:197-206.

Scalarone, G.M., Y. Mikami, N. Kurita, K. Yazawa and M. Miyaji. 1992. Comparative studies on the postantifungal effect produced by the synergistic interaction of flucytosine and amphotericin B on Candida albicans. Mycopathologia 120:133-138.

Seawell, B.W. and G.M. Scalarone. 1990. Comparison of enzyme immunoassay and immunodiffusion for the detection of canine blastomycosis. Mycoses 33:375-381.

Johnson, S.M. and G.M. Scalarone. 1988. Preparation and ELISA evaluation of Blastomyces dermatitidis yeast phase lysate antigens. Diagnostic Microbiology and Infectious Diseases 11:81-86.

Sato, H., A.S. Honigman and G.M. Scalarone. 1987. Development of a comparative Dot ELISA for the detection of antibodies in blastomycosis. Diagnostic Microbiology and Infectious Diseases 7:37-43.

Scalarone, G.M. 1987. The use of a urease-antibody conjugate in an enzyme immunoassay for the detection of blastomycosis. Journal of Medical and Veterinary Mycology 25:215-222.

Scalarone, G.M. and R.W. Huntington. 1983. Circling syndrome and inner ear disease in mice infected intraperitoneally or intravenously with Coccidioides immitis spherule-endospore phase cultures. Mycopathologia. 83:75-86.

Boyer, M.J. and G.M. Scalarone. 1983. The use of Histolyn CYL in an enzyme immunoassay to detect Histoplasma capsulatum antibodies Sabouraudia. 21:303-315.


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