Biological Sciences

Michael A. Thomas, Ph.D.

Michael A. Thomas

Professor
Director of Biology Graduate Programs
Academic Director of the Molecular Research Core Facility

Education

Biographical Sketch

Dr. Thomas joined ISU in 2003. He obtained his Ph.D. at Penn State University in 2000, working with Dr. Bruce McPheron's insect evolution group, in entomology and molecular evolutionary genetics. He then trained in bioinformatics at the Bioinformatics Research Center of the Medical College of Wisconsin's Human and Molecular Genetics Group from 2000-2003.

Dr. Thomas's group develops genomic approaches to studying complex evolutionary problems, specializing in detecting adaptive evolutionary changes. Projects involve examining the fates of duplicated genes, identifying genes involved with key evolutionary innovations, and determining the adaptive significance of genome processes involving functional modifications, such as alternative splicing and RNA editing. Recently, he began using these bioinformatics tools to examine biological implications of toxins in aquatic systems, looking specifically at nanomaterials and psychoactive pharmaceuticals.

Teaching

Publications

Ecology: Gene tweaking for conservation. 2013. MA Thomas, GW Roemer, CJ Donlan, BG Dickson, M Matocq, J Malaney. Nature 501 (7468), 485-486

High performance data clustering: a comparative analysis of performance for GPU, RASC, MPI, and OpenMP implementations. 2013. L Yang, SC Chiu, WK Liao, MA Thomas. The Journal of Supercomputing, 1-17

An ecological study on childhood autism. 2012. S St-Hilaire, V Ezike, H Stryhn, M Thomas. International Journal of Health Geographics 11 (1), 44

Psychoactive Pharmaceuticals Induce Fish Gene Expression Profiles Associated with Human Idiopathic Autism. 2012. MA Thomas, RD Klaper. PloS one 7 (6), e32917

Integrating the Alzheimer's disease proteome and transcriptome: a comprehensive network model of a complex disease. 2012. P Hallock, MA Thomas. Omics: a journal of integrative biology 16 (1-2), 37-49

Gene-class analysis of expression patterns induced by psychoactive pharmaceutical exposure in fathead minnow (Pimephales promelas) indicates induction of neuronal systems. 2012. MA Thomas, PP Joshi, RD Klaper. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology

Implications of informatics approaches in ecological research. 2011. KJ Metzger, R Klaper, MA Thomas. Ecological Informatics 6 (1), 4-12

Gene set enrichment analysis of microarray data from Pimephales promelas (Rafinesque), a non-mammalian model organism. 2011. MA Thomas, L Yang, BJ Carter, RD Klaper. BMC genomics 12 (1), 66

Evidence of positive selection at codon sites localized in extracellular domains of mammalian CC motif chemokine receptor proteins. 2010. KJ Metzger, MA Thomas. BMC evolutionary biology 10 (1)


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